Provided is a hydroxyl-protected alcohol comprising a thermolabile hydroxyl-protecting group comprising a 2-pyridyl substituent and a precursor of the thermolabile hydroxyl-protected alcohol.
The present invention provides a CpG oligonucleotide prodrug that includes a thermolabile substituent on at least one nucleotide thereof.
Compositions for an alkaline phosphatase and methods for over-expression and purification of thermolabile Antarctic phosphatase (TAP) are provided.
The present invention relates to methods for tenderizing meat, said method comprising contacting meat with a tenderizing-effective amount of a thermolabile protease.
A thermolabile DNase from the shrimp Pandalus borealis has been identified which is suitable for use in the methods of the invention.
The present invention relates to purified heat labile Bordetella toxin and to a vaccine and treatment methods comprising same.
The invention is drawn to compositions and methods for using E. coli heat labile toxin (LT) and known analogs as adjuvants in birds.
There is only a low level of sequence identity between these toxins and toxins such as cholera toxin and E.coli heat labile toxin.
Preferred mucosal immunizations are via the intranasal route using a detoxified mutant of E.coli heat labile toxin as the adjuvant.
Because the heat labile component adsorbed on the carrier survives the elevated temperature, the resulting treated surfaces exhibit properties derived from the heat labile component(s).
The present invention relates to recombinant strains of Mycobacterium that encode the mutated Escherichia coli LT heat-labile toxin or the A subunit of the mutated Escherichia coli LT heat-labile toxin.
The present invention also relates to strains of Mycobacterium that encode the LT heat-labile toxin or the A subunit of the LT heat-labile toxin of Escherichia coli mutated in position 63.
Specifically, the present invention relates to strains of Mycobacterium that encode the LT heat-labile toxin or the A subunit of the LT heat-labile toxin of Escherichia coli mutated in position 63 from serine to lysine.
The second layer may contain a hydroxyl group-containing polymer that includes a heat-labile moiety.
In one example, a toxiod heat-labile (LT) and heat-stable (STa) fusion is described.
This invention relates to a mutant E. coli heat-labile enterotoxin (LT) subunit A that can be used as an adjuvant.
A detoxified recombinant E. coli heat-labile enterotoxin mutant, LTS61K, is employed as a carrier protein to conjugate polysaccharide.
It is still more preferred that the difluoroaromatic portions of the poly(arylene ether) are modified in such a way that some difluoroaromatic portions carry a themolabile portion.
Methods and compositions are provided herein for the use of a novel mutant form of E. coli heat-labile enterotoxin which has lost its toxicity but has retained its immunologic activity.
The present invention relates to a vaccine containing at least one particulate immunogen and an adjuvanting amount of B subunits of heat-labile enterotoxin characteristic of E. Coli.
Enzymes, especially proteolytic enzymes such as bromelain, have been found to inhibit the action of heat-labile toxin (LT) of enterotoxigenic Escherichia coli.
The Escherichia coli strain may produce K88 fimbria and a fusion protein including a mutant LT enterotoxin linked with a STb enterotoxin.
A method for treating allergy with a pharmaceutical composition containing a detoxified E. coli heat-labile enterotoxin, and, optionally, an allergen.
Disclosed in certain embodiments is a solid oral dosage form comprising a heat-labile gelling agent; a thermal stabilizer; and a drug susceptible to abuse.