The submucosa involves a purified form of submucosa tissue.
Preferably, the ECM material comprises submucosa, for example, porcine small intestinal submucosa (SIS).
The submucosal tissue component of the present composition comprises the tunica submucosa of vertebrate intestine delaminated from the tunica muscularis and at least the luminal portion of the tunica mucosa.
Instruments include a safe access needle injection instrument, a submucosal tunneling instrument, a submucosal dissection instrument, and a mucosal resection device.
Such a remodelable ECM material may be comprised of submucosa from a warm-blooded vertebrate, for example, porcine small intestinal submucosa (SIS).
It is intended to provide an instrument for an endoscopic treatment which is suitable for cutting a submucous layer in an endoscopic treatment for removing the submucous layer.
The collagenous material may be small intestine submucosa (SIS).
Apparatus and methods are provided for treating female urinary incontinence by injecting a bulking agent at the interface between the mucosal and submucosal layers of the urethral wall.
The scaffold includes a biological, 5 biocompatible, or biodegradable material, such as PLGA or SIS.
The invention provides isolated bladder submucosa, optionally seeded with cells, for use in tissue reconstruction.
Advantageous such remodelable materials can include collagenous extracellular matrix materials, such as small intestine submucosa.
The present invention also provides a method for preparing the biocompatible small intestinal submucosa sheet.