A DNA encoding L-ribose isomerase which catalyzes the isomerization of L-ribose into L-ribulose and the isomerization of L-ribulose into L-ribose; and a process for producing a polypeptide by a DNA recombination technique with the use of this DNA.
A method for synthesizing L-ribose (1) and 2-deoxy L-ribose (12) from inexpensive D-ribose (2) is provided.
This disclosure provides methods for catalyzing the release of ADP-ribose from poly(ADP-ribose) or O-acetyl-ADP-ribose.
This aldehyde is a protected form of L-ribose, being L-ribose 2,3,4,5,-tetraacetate.
The compositions comprise poly ADP-ribose polymerase genes and portions thereof, particularly the maize poly ADP-ribose polymerase gene as well as antisense nucleotide sequences for poly ADP-ribose polymerase genes.
Compounds are disclosed in connection with PARG and/or PARP inhibition.
The supplements include ribose and folate.
The preferred pentose is D-ribose, to be administered chronically.
Provided herein are inhibitors of poly(ADP-ribose)polymerase activity.
The compounds have unnatural L ribose stereochemistry.
The present invention relates to a economic synthetic method of 2-deoxy-L-ribose from 2-deoxy-D-ribose with easy reaction, separation and purification.
The 5-O-trityl ribose (3) (prepared in 70 % yield from D-ribose) is reduced with borohydride to give the tetrol (4), which is then peracetylated to the tetraacetate (5).
At least some of the individual members of the primers have one or more ribose modifications that stabilize or lock the ribose ring in a 3' -endo conformation.
There are provided substituted 3-oxo -2, 3 -dihydro-1H-isoindole-4-carboxamide derivatives (I) which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2.