End of orphan work status

Mutual recognition of orphan work status

In turn, an orphan signal sequence can be used to clone, identify and isolate the corresponding orphan proteins that the orphan signal sequence directs to the surface of a cell.

whether the sponsor has obtained an orphan designation for the investigational medicinal product for an orphan condition

A novel receptor protein tyrosine kinase named ork (Orphan receptor tyrosine kinase) is identified and characterized. cDNA encoding the ork protein is inserted into an expression vector for production of the protein via recombinant DNA technology.