Disclosed is a sustained release composition of a protein drug.
The composition comprises a carrier substrate and a protein drug incorporated in the carrier substrate.
The formulations include one or more polyamino acid ligands of the protein drug.
The present invention is directed to a method for obtaining an in vitro pharmacological model of a recombinant protein drug in a given host.
Disclosed are a protein-containing lipid implant for sustained delivery, which comprises a compressed mixture of a protein drug coated with a hydrophilic polymer and a lipid, and a method of preparing the lipid implant.
The drug may, for example, be a metal-containing compound, a protein or peptide drug, and/or an organic hydrophobic compound.
By this formulation, the proteinous drug is protected from enzymatic degradation and its uptake by the intestinal tract is promoted when administered orally.