Stimulating glutamate reuptake by glutamate transporter can ameliorate excessive activation of glutamate receptors by reducing the extracellular glutamate concentration.
Glutamate racemase catalyses the interconversion of L-glutamate to D-glutamate, making D-glutamate available, which is required for bacterial peptidoglycan biosynthesis.
Stimulating glutamate reuptake by glutamate transporters can ameliorate excessive activation of glutamate receptors by reducing the extracellular glutamate concentration.
For example, excess extracellular glutamate is a cause of excessive activation of glutamate receptors.
Mono- and disodium glutamate are preferred.
Moreover, Thailand is worldwide one of the biggest MSG producers with a competitive market and the major MSG producer in Thailand fully co-operated.
The investigation showed that MSG represents less than 3 % of the cost of production of all products containing MSG produced by both companies.
This cooperating company purchased MSG from the Union industry and imported around 40 % of its total MSG purchases from China.
One interested party claimed that there was a significant difference in quality between the MSG produced in Indonesia and the MSG produced in the Union.
This trader purchased MSG mainly from the Union industry, but also from importers of MSG from Indonesia and other third countries.
The disclosed method is useful for identifying compounds that can inhibit, stimulate, or modulate the activity of the glutamate transporter and thus affect glutamate reuptake.
Such compounds are useful to treat various neurological diseases and conditions involving glutamate transporter and glutamate receptor activation.
The invention also relates to compounds and methods for modulating metabotropic glutamate receptor activity and binding to metabotropic glutamate receptors.
Glutamate Transporter Associated Proteins and nucleotide encoding Glutamate Transporter Associated Proteins are provided.
The present invention provides cell lines expressing a recombinant heteromeric AMPA glutamate receptor, preferably a human heteromeric AMPA glutamate receptor, or a recombinant human homomeric AMPA glutamate receptor.