Using the technique, methylated centromere DNA may be isolated from potentially any centromere in an organism.
An engineered centromere, and systems and methods of using the engineered centromere are described.
The present invention relates to nucleic acids which encode a functional centromere from Oryza sativa.
A psoriasis susceptibility locus has also been observed close to the centromere of human chromosome 4.
The invention is generally related to MCs containing sorghum centromere sequences.
Functional minimal segments preferably include centromeric DNA, telomeric DNA, and genomic DNA.
It should be stated whether or not centromeric switch of label is, scored as an SCE.
These include identification of the presence or absence of a kinetochore or centromeric DNA in the micronuclei.
An isolated nucleic acid is provided which encodes a transiently-expressed kinetochore protein, CENP-F. Also provided are the purified polypeptide encoded by the nucleic acid sequence, and antibodies immunologically specific for the polypeptide.
The long arrays are engineered centromere-like regions that allow one to construct mammalian artificial chromosomes with a predefined centromeric region structure.
The invention is based on the discovery that assessment of chromosomal copy number abnormalities at two or more of chromosome 5p15, 7p12, 8q24 and centromere 6 can be used for prognostic classification.
Artificial plant minichromosomes comprising a functional centromere which specifically bind centromeric protein C (CENPC) and methods for making such minichromosomes are described.