The invention provides a method for effecting the trans-differentiation of a somatic cell, i.e., the conversion of a somatic cell of one cell type into a somatic cell of a different cell type.
Expression of an oocyte-deprogramming polypeptide in the somatic cell modifyies the DNA of the somatic cell, modifies the chromatin of the somatic cell and/or remodels its chromatin.
It is intended to provide a method of inducing homologous recombination of a somatic cell at the locus of the somatic cell to thereby obtain various novel genes.
Disclosed is a method for producing a pluripotent stem cell from a somatic cell.
The method enables the production of a pluripotent stem cell from a somatic cell efficiently.
The invention relates to isolated pluripotential cells, comprising at least part of the cytoplasm derived from an embryonic stem cell/embryonic germ cell and a nucleus of a somatic cell.
The invention also provides methods for reprogramming a nucleus of a somatic cell so as to become a less differentiated stem cell.
In another aspect, there is provided a somatic cell differentiated in vitro from an undifferentiated embryonic stem cell.
Aspects of the present invention relate to compositions and methods of reprogramming a somatic cell to give rise to an autologous embryonic stem cell.
Also disclosed is a method for producing an ES-like cell from a somatic cell by using a chromosomally unintegrated virus vector.