Vector constructs useful in the expression of double-stranded RNA.
The DNA bound to the membrane matrix remains in double-stranded form.
The invention relates to a medicament containing at least one double-stranded oligoribonucleotide (dsRNA) designed to inhibit the expression of a target gene.
Disclosed are: a method for synthesizing double-stranded DNA from corresponding specific RNA at low cost and in a simple manner; and a method for amplifying the double-stranded DNA.
The present invention relates to the field of synthesis of short double-stranded RNAs.
A recombinant double stranded RNA (dsRNA) phage expresses dsRNA-encoded genes in eukaryote cells.
Methods and devices are provided for characterizing a duplex nucleic acid, e.g., a duplex DNA molecule.
The present invention relates to methods and compositions for the production of DNA and RNA, and in particular, double stranded DNA and double stranded RNA.
Therapeutic intervention with dsRNAs is also described.
The nucleases act on ssDNA, not dsDNA.
The invention also concerns cells which express a (ds)RNAase and a combination of an antisense RNA and a (ds)RNAase which are coded by one or several vectors.
According to the invention, one strand of the dsRNA is at least in part complementary to the target gene.
Disclosed is a screening method for identifying compounds capable of disrupting binding of a dsRNA-binding protein or protein complex to dsRNA.
The present invention concerns concatemer and/or stabilized RNA constructs capable of forming dsRNA, optionally comprising a sequence capable of protecting the dsRNA against RNA processing in a host cell.
The methods can be used to express double stranded RNA complexes.